C15 Deficiency Syndrome: Why Young People Get "Old People" Diseases?
Nutritional C15:0 deficiencies can cause ferroptosis, which results in accelerated aging and compromised metabolic, heart, and liver health. This syndrome is called Cellular Fragility Syndrome. Cellular Fragility Syndrome occurs when a person does not routinely get enough C15:0
via their diet or supplements. If cells are deficient in C15:0, they can become fragile and result in Cellular Fragility Syndrome, which accelerates cellular aging, the onset of ferroptosis (a newly discovered form of cell death), and downstream effects on red blood cell, metabolic, heart and liver health.
Pentadecanoic Acid (15:0) is predominantly found in dairy products, particularly goat milk from mountain grass-fed goats, as well as in egg products, butter, goat cheese, various fats and oils, lamb, veal, game, and beef. It is also present in cheeses, yogurts, sunflower oil, and a variety of seafood including salmon, oysters, swordfish, trout, shrimp, clams, perch, tuna, and haddock. A significant paper has recently been published on a newly identified nutritional C15:0 deficiency syndrome, termed Cellular Fragility Syndrome. This discovery is noteworthy as nutritional deficiency syndromes, such as vitamin C deficiency leading to scurvy or vitamin D deficiency resulting in rickets, are infrequently identified.
The recent study highlights that a lack of C15:0, a crucial fatty acid, leads to fragile cells and a process known as ferroptosis. This process, in turn, speeds up aging and negatively affects metabolic, liver, and heart health. However, the study, which was published in the peer-reviewed journal Metabolites, indicates that rectifying C15:0 deficiencies can reinforce cells, combat ferroptosis, decelerate cellular aging, and safeguard long-term metabolic, liver, and heart health. Moreover, maintaining optimal C15:0 levels could promote even greater health and longevity, akin to what is observed in Longevity Blue Zones.
C15:0 (pronounced see-fifteen) is an odd-chain saturated fatty acid. While our primary source of C15:0 is from whole fat dairy foods, this healthy fat can also be found in some types of fish and plants. Dr. Stephanie Venn-Watson, a veterinary epidemiologist, surprisingly discovered that C15:0 is an essential fatty acid - the first to be found in over 90 years.
C15:0, also known as pentadecanoic acid, actively contributes to the repair, restoration, and revitalization of our long-term health at the cellular level by:
- Strengthening cell membranes against age-related deterioration.
- Repairing mitochondrial function to sustain our cells' energy production.
- Naturally activating receptors, such as PPARs and AMPK, that regulate metabolism, immunity, mood, sleep, and appetite.
- Naturally inhibiting harmful pathways, including mTOR and JAK-STAT, to support longevity.
Overall, C15:0 offers over 36 cellular benefits that bolster our long-term health.
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