How does cleansing Zombie Cells and feeding your melanin improve your health and prolong life?Elderberry Juice, capers, Red Onions, banana Peppers, Dock (Raw), Radish Leaves, Cilantro, Dill, fennel. Oregan, Yellow Onion, Watercress, Okra, Cocoa, Bee pollen, Asparagus, Radicchio, are great sources of Quercetin!
Cells that resist normal cellular death or Zombie cells, also known as senescent cells, are cells that resist normal cellular death and continue to live even when they are too old or damaged to function properly. These cells release molecules that can cause inflammation and damage other cells and organs! Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases. One such process is cellular senescence, which entails a state of cell cycle arrest in response to damaging stimuli. Senescent cells can arise throughout the lifespan and, if persistent, can have deleterious effects on tissue function due to the many proteins they secrete. Melanin can protect the body from the DNA damage that can be the catalyst for senescent cells.
In conditions in which senescent cell burden is already high, such as obesity, dietary change toward a green diet is beneficial. Senolytics are a class of compounds that can eradicate Senescent Cell by inducing cellular apoptosis and programmed cell death. Recently, an expanding list of senolytic agents, such as a combination of Dasatinib and Quercetin (DQ), BCL inhibitors ABT-263/737, HSP90 inhibitor Cardiac glycosides and procyanidin C1 have been discovered and show the SnC-clearing effects. Among them, DQ is the first identified, and also the most characterized senolytic drug. Dasatinib is an FDA-approved tyrosine kinase inhibitor able to induce apoptosis in SnCs by inhibiting the tyrosine kinase.
Quercetin is a naturally occurring flavonoid with the ability to induce cell apoptosis through repressing the anti-apoptotic molecules. Studies have shown that the combination of dasatinib and quercetin exerted significant effects on the elimination of and the relief of SASP in various tissues. Accordingly, DQ has been tested to treat aging-related diseases such as atherosclerosis, senile osteoporosis, diabetic kidney disease, and type II diabetes. Recently, two clinical trials were approved to apply the senolytic to treat idiopathic pulmonary fibrosis (IPF), which showed the promising outcome in improving patients’ physiology, though the examination of entailing larger population of participants and the evaluation of long-term effects are needed.
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