Melanin the biochemical marker for life is studied more by the military than any other substance!
Neuro-Melanin allows you to transfer information faster and store more information than organisms with less melanin. The amount in your brain is not based on skin color or phenotype. The reason melanin is the most valuable substance on the planet is not taught by schools controlled by the system of white supremacy who would have us believe skin color denotes intelligence. Thus the Black race is under-educated, dys-education affected (dysfunctional) and mis-educated about Melanin. This fact merely reflects one particle of a global antiblack sentiment based on a fear of black empowerment and an awakening to the fact that . Black people must "Know Themselves" and to know that melanin is the true source of power not debt created promissory notes. To know yourself as a human being is to know Melanin in all its forms and its necessity.
Neuromelanin, a black pigment generated during catecholamine synthesis, is ordinarily present in dopaminergic and noradrenergic nuclei in the substantia nigra pars compacta and the locus coeruleus. Neuromelanin provides neuronal protection from oxidative stress binding metal ions, especially iron (Zucca et al.,2017). The Defense Advanced Research Projects Agency (DARPA) sets out on an initiative to develop nonsurgical neurotechnology. The nanotechnology required they found was disrupted inside people with high amounts of neuromelanin in the brain.
Prof. Newton Howard, a Brain and Cognitive Scientist, the former Director of the MIT Mind Machine Project at the Massachusetts Institute of Technology expounds on this...Now we are moving inwards and developing the tools to help us communicate with the world inside us. While the nature of tools has evolved from physical to digital, and now neural, our brain is effectively becoming the tool for interaction, communication, collaboration, and control.
From electrodes in many different shapes being implanted in the human brain to transmit and receive signals to non-invasive devices that translate brain waves into commands that control not only computer but also body parts are already becoming a reality. As a result, the thought of any technology that can be weaponized and potentially manipulate brain waves to change human behavior or control human behavior is becoming alarming. So, the question that needs to be evaluated is not whether this emerging mind-control technology can be weaponized, but when, by who, and how?
Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator Neuromelanin (NM) in the pre-synaptic terminal of dopamine neurons is emerging as a primary player in brain sciences. Drugs like crack cocaine, opioids, heroin all affect and seek to destroy neuromelanin making the human mind susceptible and weak.
This next passage will be difficult to understand for the layman so bear with me.
Interactions between neuromelanin and different molecules in the synaptic terminal and how these interactions might affect neurodegenerative disorders including PD needs to be explored more thoroughly. Neuromelanin can reversibly bind and interact with amine containing neurotoxins, e.g., MPTP, to augment their actions in the terminal, eventually leading to the instability and degeneration of melanin-containing neurons due to oxidative stress and mitochondrial dysfunction. In particular, neuromelanin appears to confer susceptibility to chemical toxicity by providing a large sink of iron-bound, heme-like structures in a pi-conjugated system, a system seemingly purposed to allow for stabilizing interactions including pi-stacking as well as ligand binding to iron.
Given the progressive accumulation of NM with age corresponding with an apparent decrease in dopamine synthetic pathways, the immediate question of whether NM is also capable of binding dopamine, the primary functional monoamine utilized in this cell, was raised. Neuromelanin serves to trap iron and provide neuronal protection from oxidative stress. This equilibrium between iron, dopamine, and neuromelanin is crucial for cell homeostasis and in some cellular circumstances can be disrupted.
Despite the rather glaring implications of this finding, this idea appears not to have been adequately addressed. As such, we postulate on potential mechanisms by which dopamine might dissociate from neuromelanin and the implications of such a reversible relationship. Melanin, an endogenous biopolymer present in living organisms, has attracted increasing attention as a versatile bioinspired functional platform owing to its unique physicochemical properties (e.g., high biocompatibility, strong chelation of metal ions, broadband light absorption, high drug binding properties) and inherent antioxidant, photoprotective, anti-inflammatory, and anti-tumor effects.
Melanin and melanin-like nanoparticles show potential clinical application and translational promise in single and multimodal imaging-guided treatment of a variety of diseases due to their fascinating properties, including excellent biocompatibility and biodegradability, inherent NIR-absorbance, radioprotection, antioxidant activity, free-radical scavenging, metal ion chelation, drug loading, and functionalized modifications. This means neuromelanin can help remove metals (chelate) utilized for nanobot technology as well as facilitate its efficacy!
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